Project

Cross section of  electrospun polymer fibers
Cross section of electrospun polymer fibers

The project ‘Nanofiber-based sponges for atopic skin treatment’ funded by Foundation for Polish Science started in October 2018. This international project is the collaboration with Harvard Medical School, Massachusetts Institute of Technology (USA) and Technion (Israel). The aim of the project is to understand and control emollient or oil release from nanofibers patches for atopic skin for babies, kids and adults. Within this project we want to provide the best way to control the release of curing substances from newly developed patches based on electrospun polymer. We will compare the curing effects of emollients and mineral oils with the essential oils, that will be captured in the patches. The highly porous patches will be used as sponges for soaking oils and emollients to help hydrate skin, reduce itching and redness associated with atopic skin problems and many allergies. A long and slow release of oils/emollients through patches will reduce the need of very frequent application of body lotion. The proposed treatment, based on the new designs of patches, is going to have a remarkable effect on the skin condition. Nanofibers will be produced via electrospinning and characterized with advanced microscopy and 3D tomography based on Focus Ion Beam and Scanning Electron Microscopy (FIB-SEM) to verify the nanostructure of fibers and patches and the wetting effects between oils and polymer surfaces.

Publications

2022

Kaniuk, Ł.; Berniak, K.; Lichawska-Cieślar, A.; Jura, J.; Karbowniczek, J. E.; Stachewicz, U., "Accelerated wound closure rate by hyaluronic acid release from coated PHBV electrospun fiber scaffolds.", Journal of Drug Delivery Science and Technology. 103855, 5 October 2022.
OPEN ACCESS
https://doi.org/10.1016/j.jddst.2022.103855

Z. J. Krysiak, U. Stachewicz, "Electrospun fibers as carriers for topical drug delivery and release in skin bandages and patches for atopic dermatitis treatment", WIREs Nanomedicine and Nanobiotechnology. e1829, 11 July 2022
https://wires.onlinelibrary.wiley.com/doi/10.1002/wnan.1829

Z. J. Krysiak, U. Stachewicz, "Urea-Based Patches with Controlled Release for Potential Atopic Dermatitis Treatment", Pharmaceutics 2022, 14(7), 1494
OPEN ACCESS
https://www.mdpi.com/1999-4923/14/7/1494

E. A. Sroczyk, J. A. Bryant, F. de Cogan, J. Knapczyk-Korczak,P. K. Szewczyk, M. Banzhaf, M.; U. Stachewicz, "Modification of Electrospun PI Membranes with Active Chlorine for Antimicrobial Skin Patches Applications", Applied Surface Science 2022, 1–21
https://www.sciencedirect.com/science/article/pii/S0169433222008583

Z. J. Krysiak, P. K Szewczyk, K. Berniak, E. A. Sroczyk, E. Boratyn, U. Stachewicz, "Stretchable skin hydrating PVB patches with controlled pores’ size and shape for deliberate evening primrose oil spreading, transport and release.", Biomaterials Advances, 136, 212786, 2022
OPEN ACCESS
https://www.sciencedirect.com/science/article/pii/S2772950822000632?via%3Dihub

Ł. Kaniuk, A. Podborska, U. Stachewicz, "Enhanced mechanical performance and wettability of PHBV fiber blends with evening primrose oil for skin patches improving hydration and comfort", Journal of Materials Chemistry B, 10, 1763 – 1774, 2022
OPEN ACCESS
https://pubs.rsc.org/en/content/articlelanding/2022/tb/d1tb02805g

E. A. Sroczyk, K. Berniak, M. Jaszczur, U. Stachewicz, "Topical Electrospun Patches Loaded with Oil for Effective Gamma Linoleic Acid Transport and Skin Hydration towards Atopic Dermatitis Skincare", Chemical Engineering Journal, 132256, 2022
OPEN ACCESS
https://doi.org/10.1016/j.cej.2021.132256

2021

Ł. Kaniuk, U. Stachewicz, "Development and Advantages of Biodegradable PHA Polymers Based on Electrospun PHBV Fibers for Tissue Engineering and Other Biomedical Applications", ACS Biomaterial Science and Engineering, 12, 5339–5362, 2021
OPEN ACCESS
https://doi.org/10.1021/acsbiomaterials.1c00757

Ł. Kaniuk, S. Ferraris, S. Spriano, T. Luxbacher, Z. Krysiak, K. Berniak, A. Zaszczynska, M. Marzec, A. Bernasik, P. Sajkiewicz, U. Stachewicz, "Time-dependent effects on physicochemical and surface properties of PHBV fibers and films in relation to their interactions with fibroblasts", Applied Surface Science, 545, 148983, 2021
https://www.sciencedirect.com/science/article/pii/S0169433221000593

Z. J. Krysiak, J. Knapczyk – Korczak, G. Maniak, U. Stachewicz, "Moisturising effect of skin patches with hydrophobic and hydrophylic electrospun fibers for atopic dermatitis", Colloids and Surfaces B: Biointerfaces, 199, 111554, 2021
https://www.sciencedirect.com/science/article/abs/pii/S0927776520309115

S. Metwally, D. P. Ura, Z. J. Krysiak, Ł. Kaniuk, P. K. Szewczyk, U. Stachewicz, "Electrospun PCL Patches with Controlled Fiber Morphology and Mechanical Performance for Skin Moisturization via Long-Term Release of Hemp Oil for Atopic Dermatitis", Membranes 2021, 11(1), 26
OPEN ACCESS
https://www.mdpi.com/2077-0375/11/1/26/htm

2020

Z. J. Krysiak, Ł. Kaniuk, S. Metwally, P. K. Szewczyk, E. Sroczyk, P. Peer, P. Lisiecka-Graca, R. J. Bailey, E. Bilotti, U. Stachewicz, "Nano- and Microfiber PVB Patches as Natural Oils Carriers for Atopic Skin Treatment", ACS Applied Bio Materials, 3, 11, 7666–7676, 2020
OPEN ACCESS
https://pubs.acs.org/doi/10.1021/acsabm.0c00854

Aleksandra Ivanoska-Dacikj and Urszula Stachewicz, "Smart textiles and wearable technologies – opportunities offered in the fight against pandemics in relation to current COVID-19 state", Review on Advanced Materials Science, 59(1), 487-505, 2020
OPEN ACCESS
https://www.degruyter.com/view/journals/rams/59/1/article-p487.xmln

P. K. Szewczyk and U. Stachewicz, "Collagen Fibers in Crocodile Skin and Teeth: A Morphological Comparison Using Light and Scanning Electron Microscopy", Journal of Bionic Engineering, 17, 1-8, 2020
OPEN ACCESS
https://link.springer.com/article/10.1007/s42235-020-0059-7

S. Metwally, S. Ferraris, S. Spriano, Z. J. Krysiak, Ł. Kaniuk, S-K. Kim, P. K. Szewczyk, M. M. Marzec, A. Gruszczyński, M. Wytrwał-Sarna, A. Bernasik, S. Kar-Narayan, U. Stachewicz, "Surface potential and roughness controlled cell adhesion and collagen formation in electrospun PCL fibers for bone regeneration", Materials and Design, 194, 108915, 2020
OPEN ACCESS
https://www.sciencedirect.com/science/article/pii/S0264127520304494?via%3Dihub

S. Metwally, U. Stachewicz, "Teeth resorption at cement - enamel junction (CEJ) - Microscopy analysis", Micron 137 (2020) 102913
OPEN ACCESS
https://www.sciencedirect.com/science/article/pii/S0968432820301621?via%3Dihub

Z. J. Krysiak, M. Z. Gawlik, J. Knapczyk – Korczak, Ł. Kaniuk, U. Stachewicz, "Hierarchical composite meshes of electrospun PS microfibers with PA6 nanofibers for regenerative medicine", Materials, 13(1974), 2020
OPEN ACCESS
https://www.mdpi.com/1996-1944/13/8/1974/htm

Ł. Kaniuk, Z. J. Krysiak, S. Metwally, U. Stachewicz, "Osteoblasts and fibroblasts attachment to poly(3-hydroxybutyric acid-co-3-hydrovaleric acid) (PHBV) film and electrospun scaffolds", Materials Science and Engineering C, 110, 110668, 2020
OPEN ACCESS
https://www.sciencedirect.com/science/article/abs/pii/S0928493119340986?via%3Dihub

2019

S. Metwally, S. Martínez Comesaña, M. Zarzyka, P.K. Szewczyk, J.E. Karbowniczek, U. Stachewicz, "Thermal insulation design bioinspired by microstructure study of penguin feather and polar bear hair", Acta Biomaterialia, 91, 270-283, 2019
https://www.sciencedirect.com/science/article/pii/S1742706119302740

P. K. Szewczyk, S. Metwally, Z. J. Krysiak, Ł. Kaniuk, J. E. Karbowniczek, U. Stachewicz, "Enhanced osteoblasts adhesion and collagen formation on biomimetic polyvinylidene fluoride (PVDF) films for bone regeneration" Biomedical Materials 14, 065006, 2019
https://iopscience.iop.org/article/10.1088/1748-605X/ab3c20